hrp0095p1-145 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Spatial navigation and memory in transgender male adolescents treated with gender affirming hormones

Perl Liat , Oren Asaf , C. Mueller Sven , Raphael Ido , Borger Ophir , Sheppes Tamar , Shechner Tomer

Background: Spatial navigation is an essential human skill that helps individuals track their changes in position and orientation by integrating self-motion cues. Meta-analyses indicate that males, on average, perform better than females on a number of spatial tasks. Sex steroids, mainly androgens, modulate the remodeling of synapses in the prefrontal cortex and hippocampus, a limbic brain area with critical influence on spatial and contextual memory. Androgen...